The CDC has listed substance use disorders, schizophrenia spectrum disorders, and mood disorders, including depression as underlying medical conditions associated with higher risk for severe COVID-19.
Individuals with comorbidities are encouraged to be vaccinated against COVID-19, including a booster.
Detailed information is available on CDC’s Underlying Medical Conditions Associated with Higher Risk for Severe COVID-19: Information for Healthcare Providers webpage, updated October 14, 2021.