From NIH. Previously unrecognized pathways in mice have relevance for mental health and addiction research. Researchers have identified connections between neurons in brain systems associated with reward, stress, and emotion. Conducted in mice, the new study may help untangle multiple psychiatric conditions, including alcohol use disorder, anxiety disorders, insomnia, and depression in humans. “Understanding these […]
Research
Notification of patient overdose deaths reduces clinician opioid prescriptions
From NIH. NIH-funded study shows clinicians reduced prescriptions following behavioral “nudge.” Clinicians were more likely to reduce the number and dose of opioid drugs they prescribed after learning that one of their patients had died from an overdose from a controlled substance than those not notified, according to a recent study appearing in the August […]
Tech Takes on Cigarette Smoking
From ScienceDaily Researchers develop system that senses smoking movements, sends motivational text messages, videos to help users quit smoking Researchers at Case Western Reserve University are using wearable sensor technology to develop an automatic alert system to help people quit smoking. The smart-phone app, initially limited to android-based operating systems, automatically texts 20- to […]
MMWR: MRSA among persons who inject drugs
From CDC. Invasive Methicillin-Resistant Staphylococcus aureus Infections Among Persons Who Inject Drugs — Six Sites, 2005–2016 June 8, 2018 / 67(22);625-628 In the United States, age-adjusted opioid overdose death rates increased by >200% during 1999–2015, and heroin overdose death rates increased nearly 300% during 2011–2015 (1). During 2011–2013, the rate of heroin use within the past year […]
DOTS Study Finds Fentanyl and Polydrug Use in Patients Seen During Opioid Overdose Spike in Baltimore
DOTS Bulletin. June 2018. Issue 2.
Opioid therapy may not always work for chronic pain
From NIH NIH study explains why opioid therapy may not always work well for chronic pain Researchers have shown that pain-induced changes in the rat brain’s opioid receptor system may explain the limited effectiveness of opioid therapy in chronic pain and may play a role in the depression that often accompanies it. These findings clearly […]
New Study Suggests Overdose Deaths Now Caused Mainly By Synthetic Opioids
From JAMA. 2018;319(17):1819-1821. doi:10.1001/jama.2018.2844 Changes in Synthetic Opioid Involvement in Drug Overdose Deaths in the United States, 2010-2016 Drug overdose deaths are at unprecedented levels in the United States.1 Prescription opioids have been the most common drug involved in overdose deaths, but heroin and synthetic opioids (primarily illicit fentanyl) are increasingly implicated in overdoses.2 In addition, synthetic opioids […]
Study upends conventional view of opioid mechanism of action
From NIDA. NIH-funded scientists find new molecular target for developing safer pain medications. A new discovery shows that opioids used to treat pain, such as morphine and oxycodone, produce their effects by binding to receptors inside neurons, contrary to conventional wisdom that they acted only on the same surface receptors as endogenous opioids, which are […]